Izilingo Zomtholampilo

Inhloso: Inhloso yalolu cwaningo ukuhlola amaphrofayili e-pharmacokinetic kanye ne-pharmacodynamic (PK-PD) e-lispro elawulwa umjovo wejethi ongenazinaliti we-QS-M ezifundweni zesiShayina.

Idizayini nezindlela zocwaningo: Ucwaningo olungahleliwe, oluyimpumputhe kabili, oluyi-dummy, oluphambanayo lwenziwa. Kwabuthwa amavolontiya anempilo eyishumi nesishiyagalombili. I-Lispro (amayunithi angu-0.2/kg) yayilawulwa umjovo wejethi ongenanalithi we-QS-M noma ngepeni elivamile. Ukuhlolwa kwe-euglycemic clamp kwamahora ayisikhombisa kwenziwa. Amavolontiya ayishumi nesishiyagalombili (abesilisa abayisishiyagalolunye nabesifazane abayisishiyagalolunye) abuthwa kulolu cwaningo. Inqubo yokufaka yayiyi: abangabhemi abaneminyaka engu-18-40, abane-body mass index (BMI) ye-17-24 kg / m2; izifundo ezinokuhlolwa okujwayelekile kwe-biochemical, umfutho wegazi, ne-electrocardiograph; izihloko ezisayine imvume enolwazi. Imibandela yokukhishwa kwakuyilezi: abantu abane-insulin yokungezwani komzimba noma omunye umlando wokungezwani nomzimba; abantu abanezifo ezingamahlalakhona ezifana nesifo sikashukela, izifo zenhliziyo nemithambo yegazi, isibindi noma isifo sezinso. Izifundo eziphuze utshwala nazo azifakwanga. Ucwaningo lugunyazwe iKomidi Lezimiso Zokuziphatha Lesibhedlela Esisebenzisanayo Sokuqala sase-Chongqing Medical University.

Imiphumela: Indawo enkudlwana engaphansi kwejika (AUCs) yokugxila kwe-insulin kanye nesilinganiso sokufakwa kwe-glucose (GIR) phakathi nemizuzu yokuqala engama-20 ngemva kokujova i-lispro ngomjovo wejethi uma kuqhathaniswa nepeni le-insulin yabonwa (24.91 ± 15.25 vs. ± 0.24 vs. 0.10 ± 0.04 U min L−1, P <0.001 ye-AUCINS, 0–20 min). Umjovo ongenanaliti ubonise isikhathi esifushane sokufinyelela ekugxilweni kwe-insulin ephezulu (37.78 ± 11.14 vs. 80.56 ± 37.18 min, P <0.001) kanye ne-GIR (73.24 ± 29.89 vs. 116.18 ± 51.89 min, P = 0.0). Kwakungekho mehluko ekuchayekeni okuphelele kwe-insulin kanye nemiphumela ye-hypoglycemic phakathi kwamadivayisi womabili. Isiphetho: I-Lispro elawulwa umjovo ongenanalithi we-QS-M iphumela ekuchayekeni kwe-insulin kwangaphambilini nangaphezulu kunepeni elivamile, kanye nomthelela omkhulu wangaphambi kwesikhathi wokwehlisa ushukela onamandla afanayo jikelele.